Canada's Trudeau Wiggeling Out of Promise to Legalize MJ

During his political campaign last year, Trudeau made an explicit promise to end the prohibition of MJ.

Now that he is in office, he attempts to wiggle out, saying that he is precluded by international treaties.

Never-mind that such treaties include a provision fro nations to opt out.

Is this the result of some sort of political blackmail?  Perhaps the result of him making a bad deal for his success making him beholden to the very forces behind prohibition?

https://reason.com/blog/2016/01/07/canada-needs-permission-from-internation#comment

Italian Authorities Lie About Coca Tea

Continuing a century plus long criminal endeavor to protect Coffee and particularly cigarettes

- article falsely states that coca tea contains cocaine hci, when in fact it contains cocaine in its natural state

-authorities make deceptive statement of product being "dangerous", when in fact the danger is to market share for caffeine and nicotine containing products, rather than human health

- indeed authorities provide zero basis, particular;y in citing example of truck driver with an exemplary record.


- authorities engage in criminal restraint of trade, displaying Italy as if run by a Mafia

- practice of charging people with illicit cocaine use from drinking coca tea upon drug testing highlights irresponsibility of drug testing authorities in failing to devise tests that distinguish between use of coca and that of isolated cocaine, which are feasible based upon coca containing additional components that drug testing entities are too lazy to test for.

- drug testing likewise fails to distinguish between excessive amounts of cocaine nor any actual showing of impairment.  Such tests ought to be set at a threshold higher than the amount derived from drinking a few cups of Coca tea.  That they are not, is indicative of the drug war being all about protecting markets for caffeine and nicotine, and not about protecting health/guarding against actual drug abuse.


http://www.thelocal.it/20151222/cocaine-herbal-tea-pulled-from-italy-shelves

Word is that this sociopathic market control policy is being felt more broadly, as authorities in such nations as conquistador occupied Peru are now blocking Coca tea exports.   Would not it be nice that Peru could one day get a legitimate government representing its interests over that of the Spanish-Catholic inquisition.

Coca 'Community Session' Panel at Drug Policy Alliance Conference

The first Coca panel  at a DPA conference ever- though not as a plenary or workshop,
some 20 years after the last and only Coca panel - as a workshop - at the DPA predecessor organization's conference, the Drug Policy Foundation, moderated by yours truly in 1995

Coca: A Missing Frontier in Drug Policy Reform
Rosslyn 2 | 8:30am – 9:30am

Coca and coca-derived substances lie at the heart of drug policy, enforcement and use in Latin America, yet it is an often overlooked topic in drug policy reform circles. This community session will provide a background to coca, will stimulate discussion on how we can best approach and address coca cultivation and markets, and will consider how we can connect this issue to the wider drug policy reform movement. -

http://www.reformconference.org/community-sessions/list-2015-community-sessions

Despite the early hour - 8:30 AM, the panel was attended by about 25 people.

http://freedomofmedicineanddiet.blogspot.com/2013/06/coca-95-dpf-panel-october-21-1995.html

http://freedomofmedicineanddiet.blogspot.com/2009/11/14-years-ago-coca-95.html

Cocaine Content of Some Early 20th Century Products

and USDA prosecutions with zero showing of any actual harms from the cocaine content


https://books.google.com/books?id=Z_OQycfkoasC&pg=PA84&lpg=PA84&dq=cocaine+content+soft+drinks&source=bl&ots=mhN0XhP7t2&sig=Pv8LlyLyhd-tG5pQV_jTyJ-V6Tw&hl=en&sa=X&ei=-J4HVeXXMqm_sQSE5ID4CA&ved=0CEUQ6AEwBzgK#v=onepage&q=cocaine%20content%20soft%20drinks&f=false

Cocaine content of beverages in milligrams per fluid ounce

Wiseola        under 1 mg

Celery Cola        under 1 mg

Koca Nola        under 1 mg

Kola Coca        5 mg

Vin Mariani        6-8 mg

Kola Cardinette    9 mg

Maltine with Coca    9 mg

Coca Cordial        30 mg

Metcalf Coca Wine    32 mg

Wiseola- under 1 mg per fluid ounce

Celery Cola - under 1 mg per fluid ounce

http://continuingcounterreformation.blogspot.com/2015/06/20th-century-pharmacratic-inquisition.html

Simply declare cocaine unsafe, without any mention of dilution-concentration factor whatsoever.

Koca Nola

This was a syrup for flavoring soda water and similar "soft drinks" put up by a company of the same name at Atlanta, Ga. This "Delicious Dopeless Koca Nola"—as the label had it —was found to contain cocain. Cocain being deleterious to health, was declared an adulteration under the act so that the Koca Nola Company was found guilty on two points: (1) failing to declare the presence of cocain and (2) adulteration. The Government made two seizures and the company was found guilty in each case and a fine of $25 on each count was imposed, making the total $100.—[Notice of Judgment, No. 202.]

Celery Cola

Celery-Cola, marketed by the Birmingham Celery Cola Company of Birmingham, Ala., was another soft drink found to contain cocain and caffeine. The government contended that as cocain was a poisonous and deleterious ingredient, the product was adulterated and as the proportion or quantity of cocain was not declared on the label it was also misbranded.— [Notice of Judgment, No. 326.]

Such prosecutions did not involve excessive dosing.

Koca Nola and Celery Cola for instance each contained under 1 milligram of cocaine per fluid ounce.

Since cocaine was an ingredient required to be listed- how could it be declared an illegal ingredient, its presence automatically constituting "adulteration"?!   Should not the prosecutions as those against Coca Nola and Celery Cola have then been only for "misbranding"?

Whether or not a product even labeled its cocaine content apparently would not shield it from prosecution by Wiley's USDA Bureau of Chemistry- at least for such in food products as beverages, as with the prosecution of the manufacturers of a product named"Dr. Don's Kola":

Dr. Don's Kola

This product, which was sold as a flavoring extract for "soft drinks," was shipped by the Warner-Jcnkinson Company of St. Louis from Missouri to Michigan. When analyzed by the Government chemists, the product was found to be a syrupy liquid consisting essentially of cocain, caffein, phosphoric acid, sugar, flavoring and coloring agents, and water. It contained no substance derived from the cola nut or cola plant. In view of the fact that it contained cocain, a dangerous drug, the stuff was declared adulterated and, inasmuch as it contained no product of the cola nut. it was further declared misbranded. The defendant entered a plea of guilty and a fine was imposed.—[Notice of Judgment, No. 724.]

That prosecution apparently made no mention of any failure to label the cocaine content, being cited for "mislabeling" only insofar as failing to contain its labeled Kola nut.



USDA Prosecutions of Cocaine Containing Products
http://freedomofmedicineanddiet.blogspot.com/2008/03/new-dark-ages-usda-crusade-against-coca.html

Medicinal Coca

http://www.henriettes-herb.com/eclectic/bpc1911/erythroxylon.html

Botanical name: 

Erythroxylum coca

Erythroxylum novogranatense var. truxillense

Coca leaves are the product of Erythroxylum Coca, Lam. (Bolivian or Huanuco leaves), and of E. truxillense, Rusby (Peruvian or Truxillo leaves), shrubs (N.O. Lineae) cultivated in Bolivia, Peru, and Ceylon whence the leaves are imported into Europe. Coca, U.S.P., must yield not less than 0.5 per cent. of the ether-soluble alkaloids of coca. Bolivian coca leaves are oval in outline and vary from 3.5 to 7 centimetres in length, and from 25 to 35 millimetres in breadth. They are brownish-green in colour and are generally well preserved. The veinlets are prominent on the upper surface, and the midrib, which projects at the apex, in the form of a minute horny apiculus, is seen under the lens to lie in a depression, and to bear a distinct raised ridge on the upper surface. On the under surface of the leaf two curved lines run from base to apex on each side of the midrib. The odour is faint but characteristic, and the taste is slightly bitter, followed by a sensation of numbness. Truxillo leaves are generally rather smaller than the Bolivian variety, more broken, and pale green in colour. The ridge above the midrib and the curved lines on each side of it are less distinct, and the veinlets much less prominent on the upper surface. They are occasionally mixed with flowers of a species of Inga, an intentional addition made with the object of improving the drug. Ceylon leaves which are imported into this country in considerable quantities are the leaves of E. Coca; they resemble Bolivian leaves, but are usually larger, and are said to contain rather less alkaloid. Coca leaves from Java are derived from E. Coca, var. spruceanum, Burck.; they are exported in the crushed state from Java to Germany via Amsterdam and yield about 0.7 per cent. of total alkaloid, part of which is benzoyl-pseudo-tropine or tropacocaine. Young (Java) leaves, carefully dried have been found to contain as much as 2 per cent. of alkaloid. As the cocaine is easily hydrolysed it is desirable that the leaves should be free from mildew and kept in a dry place.

Constituents.—Coca leaves contain the alkaloids cocaine (methyl-benzoyl-ecgonine), cinnamyl-cocaine (methyl-cinnamyl-ecgonine), and truxilline (isatropyl-cocaine or cocamine). The total amount yielded by the commercial leaves varies from about 0.1 to 1.0 per cent. As a rule Truxillo leaves contain rather more alkaloid than Bolivian, but only about one-half of it is cocaine, whereas from three-fourths to five-sixths of the total alkaloid in Bolivian leaves consists of cocaine. The latter are to be preferred for medicinal use. Coca leaves also contain cocatannic acid. Java coca contains tropacocaine and four yellow crystalline glucosides, in addition to the other constituents.

Action and Uses.—The properties of coca are virtually those of cocaine (see Cocaina) (not scanned), though preparations of the whole drug appear rather more stimulating and possess a mild astringency. In Peru and Bolivia, coca leaves are chewed for their effect in relieving hunger and fatigue. The leaves of commerce are not so active in this respect as the freshly dried drug used where it is found native. Coca leaves are used as a cerebral and muscle stimulant especially during convalescence. The drug relieves gastric pain, nausea and vomiting. Coca is usually administered in the form of one of the preparations. The liquid extract contains some wax from the leaves, which is precipitated when mixed with water. The miscible liquid extract is free from this objection. Extractum Cocae is dispensed in pills and pastilles. The latter are sucked for their local action and for their stimulating effect. Vinum Cocae and Elixir Cocae are more pleasant forms of administering the drug. In cases of poisoning by preparations of coca the antidotes described under Cocaina should be employed.
Dose.—2 to 8 grammes (30 to 120 grains).

PREPARATIONS.

Also: Cocaine nasal bougies - Cocaine urethral bougies - Cocaine Eye Drops - Menthol and Cocaine Snuff - Cocaine Spray - Atropine Eye Ointment with Cocaine - Cocaine Eye Ointment - Oleinate of Cocaine - Soluble Cocaine Tablets - Strong Soluble Cocaine Tablets

Elixir Cocae, B.P.C.—ELIXIR OF COCA. 1 (miscible liquid extract) in 6.

A palatable preparation of coca for use as a cerebral stimulant and gastric sedative. Dose.—4 to 15 mils (1 to 4 fluid drachms).

Extractum Cocae, B.P.C.—EXTRACT OF COCA.

Prepared by evaporation of the liquid extract. Dose.—1 to 6 decigrams (2 to 10 grains).

Extractum Cocae Liquidum, B.P.—LIQUID EXTRACT OF COCA.

 

Coca leaves, in No. 20 powder, 100; alcohol (60 per cent.), sufficient to produce 100. Macerate the drug with 200 of alcohol for forty-eight hours, then transfer the mixture to a percolator, and percolate with sufficient alcohol to exhaust the drug. Reserve the first 75 of percolate; evaporate the remainder, at a temperature below 80°, to a soft extract, dissolve this in the reserved portion, and add sufficient alcohol to make up to the required volume. Liquid extract of coca is prescribed in mixture form or diluted with glycerin and syrup. It forms a turbid mixture with water, its waxy constituents being precipitated. Miscible liquid extract of coca is without this disadvantage. The content of total alkaloid in liquid extract of coca is very variable, ranging from 0.2 to 0.8 per cent., the average being about 0.38 per cent. This uncertainty in its composition causes the preparation to be little used. Dose.—2 to 4 mils (½ to 1 fluid drachm).

Extractum Cocae Liquidum Miscibile, B.P.C.—MISCIBLE LIQUID EXTRACT OF COCA. 1 in 1.

Miscible liquid extract of coca is free from the wax of the official liquid extract and forms a clear solution with water. It is usually weaker in total alkaloid than the official liquid extract. Dose.—2 to 4 mils (½ to 1 fluid drachm).

Fluidextractum Cocae, U.S.P.—FLUIDEXTRACT OF COCA.

 

Coca leaves, in No. 40 powder, 100; alcohol (49 per cent.), a sufficient quantity. The finished product should contain 0.5 per cent. w/v of ether-soluble alkaloids of coca. Average dose.—2 mils (30 minims).

Tinctura Cocae, B.P.C.—TINCTURE OF COCA. 1 in 5.

 

Used as a cerebral stimulant and gastric sedative. Dose.—2 to 4 mils (½ to 1 fluid drachm).

Vinum Cocae, B.P.C.—COCA WINE. 1 (elixir) in 8.

 

This is a strongly medicated wine. In order that it may be included in the class of medicated wines for sale without a wine licence, it must contain not less than half a grain of alkaloid per fluid ounce. Acts mainly in virtue of its cocaine. Coca wine differs from tea, in that the former beverage acts mainly on the motor areas and the latter on the psychical, Dose.—8 to 15 mils (2 to 4 fluid drachms) with water.

Vinum Cocae, U.S.P.—WINE OF COCA.

 

Fluidextract of coca, 6.5; alcohol (95 per cent.), 7.5; sugar, 6.5; red wine, sufficient to produce 100. Average dose.—16 mils (4 fluid drachms).

Vinum Cocae et Quininae Phosphatis, B.P.C.—COCA AND QUININE PHOSPHATE WINE.

 

Each fluid ounce contains 1 grain of quinine sulphate, 30 minims of liquid extract of coca, 4 minims of diluted phosphoric acid, with alcohol, detannated sherry and distilled water. Dose.—15 to 60 mils (½ to 2 fluid ounces).

Vin Mariani- The Latter Years

Historical accounts of Vin Mariani focus perhaps exclusively upon the years prior to the prohibition era.

Here is a bit of the history following the 1906 U.S. Food and Drug Act that effectively blacklisted cocaine via including it on a list of ingredients that had to be labeled, though not including the other popularly used stimulants of caffeine and nicotine.

1907: Vin Mariani for the U.S. market deleted the cocaine, adding a rear side label- see below.  I don't yet have information if they continued to provide the regular version as an alternative.

GUARANTEED BY MARIANI & Co. UNDER THE FOOD AND DRUGS ACT JUNE 30, 1906; SERIAL No. 448

VIN MARIANI

[MARIANI WINE]

17 PER CENT ALCOHOL BY VOLUME

AN IMPORTED FRENCH BORDEAUX WINE WITH A SPECIAL 

PROCESSING OF LEAVES OF ERYTHROXYLON COCA

PREPARED AND BOTTLED AT OUR NEW YORK FACILITY 

MARIANI AND COMPANY

PARIS, FRANCE: 41 Boulevard Haussman.   NEW YORK: 52 West 15th Street

  "THE STANDARD OF MARIANI PREPARATIONS, established by us in France nearly half a century, ago is based upon the adaptation of Coca as employed by the Andeans during hundreds of years as a force sustainer.  WE HAVE ALWAYS emphasized our use of Coca leaves chosen for AROMATIC and MEDICINAL qualities and, as we have never considered the negligible amount of alkaloid in such leaves essential to our formula, our processing completely eliminates it from our preparation”

That was actually a bad move for it implied that cocaine was something that did not belong in dilute amounts, never-mind that the real problems with cocaine came with it in concentrated forms, and that there was never any showing that cocaine in dilute form was any more "dangerous" than such other naturally occurring stimulant alkaloids as caffeine and nicotine,, both used in dilute form and both likewise poisonous in concentrated forms.

The 1906 Act neither banned cocaine as an ingredient in food or drug products.  It simply required labeling the cocaine content- itself a reasonable requirement, though actually misleading - by not likewise require the labeling of caffeine and nicotine it created a false assumption of cocaine being somehow more dangerous in likewise dilute form.

However the 1906 Act would serve as a means to bring about the deletion of dilute cocaine, via its un-fetted delegation of regulatory power to declare an ingredient unsafe to the Bureau of Chemistry of the U.S.D.A.

That started happening in 1907 with U.S.D.A. prosecutions not only against manufacturers for 'mislabeling' for failing to label the cocaine content, but others for adulteration for containing cocaine- even if properly label, with the U.S.D.A. declaring without basis that such cocaine content was dangerous.  For instance, though Wiley was well known for his "poison squad" experimentations upon food containing various substances used as preservatives, he apparently never conducted any such researching upon beverages that contained cocaine.


Such 'adulteration' prosecutions by the U.S.D.A. were done with products sold as foods.  Never-mind that the 1906 Act's inclusion of cocaine as an ingredient that had to be labeled in food and drug products implicitly meant that it remained legal.

Perhaps as a way of bolstering his authority to ban substances by declaring them unsafe Harvey Wiley initiated a famous prosecution against the Coca Cola Company for containing added caffeine- that is caffeine in pure form as a dilute ingredient- for he not only never targeted Coffee or Tea but actually praised them.

Such prosecutions would only go after products sold as foods, and hence could conceivably be sold as drugs.  However the political campaign being carried out by the U.S.D.A. Chemistry Bureau Chief Harvey Wiley - who was also prominent in the American Medical Association and its allied American Pharmaceutical Association - also targeted cocaine containing medicinal preparations via a massive lobbying effort of 'model legislation' for the individual U.S. States to ban the sale of such outside of a physicians prescription, with such prescriptions being mandated a s"non-refillable".

Political machinations in the 1908 to 1914 period would work upon amending the 1906 Act to outright ban products containing any amount of cocaine and to severely restrict those containing at least above a certain amount of opiates- efforts that culminated in 1914 with the U.S. Harrison Act.  While the particular political fear of cocaine was sold in newspapers as a fear of Negroes in the south, a 1910 U.S.D.A. Farmer Bulletin article more honestly presented the U.S.D.A.'s fear of Coca being sold and used as a "Tobacco Habit Cure".

That Act would exempt products containing below a certain amount of opiates though not of cocaine from over the counter -- that is without a physician's prescription -- from a deceptively innocuous appearing to some tax requirement, to be administered by a U.S. Department of Treasury that was not actually required to honor requests for market participation thus effectively empowering that entity to enact a virtually blanket prohibition.  This delegation of regulatory authority would be upheld by a U.S. Judge who had served in the U.S. Congress from 1909 until his resignation in 1914, and who was present in deliberations regarding amending the 1906 Food and Drug Act leading to the crafting of the 1914 Harrison Act: James Harry Covington.

As requiring non refillable prescriptions for products containing any amount of cocaine effectively made their sale and use impractical -- e.g. by requiring a separate physicians visit for each non refillable prescription -- cocaine containing preparations dissipated from OTC sales, with any such prescriptions effectively confined to a far narrower spectrum of uses, such as the use of the more concentrated  preparations in surgical anesthesia.  Any physician considering prescriptions outside of such a narrow range of uses would likewise soon be effectively cowed by the U.S. Treasury Department's abuse of its delegated regulatory authority to essentially practice medicine without a license.

Other nations would adopt such polices, though for a time some exempted dilute cocaine products as Vin Mariani.  Conceivably, Vin Mariani was produced in different versions for different market jurisdictions, though such information so far remains elusive.

http://freedomofmedicineanddiet.blogspot.com/2008/03/us-state-departments-opium-convention.html

1938

1938

1946- this shows the classic Vin Mariani bottle

1938

According to an article by Walter Helfland, Vin Mariani was sold in some form until 1963.

Dilute Cocaine in Vin Mariani, Coca-Cola & Harvey Wiley - According to Steven B. Karch

A Brief History of Cocaine - Steven B. Karch

pp 100-102

If our drug policies appear convoluted today, think how they must have looked to the owners of the Coca-Cola Company just after the turn of the century.  In 1911, company officials found themselves in federal court, charged with, among other things, not putting cocaine in Coca- Cola.  Popular histories of this period usually lump Coca-Cola with the [sic] other quack nostrums [sic- a nostrum is simply a medicated liquid meant to be take orally], often suggesting that the problem of cocaine abuse in America was, in some way, connected to the successes of the Coca-Cola Company.  Except for the titillation factor, the idea has little to recommend it.  Even when Coca-Cola contained cocaine, the amounts were trivial; too small to produce measurable physiological or behavioral changes.  Coca-Cola was not responsible for America's cocaine problem, but government harassment of the Atlanta soft drink maker did mark an important turning point in the development of American drug policy, and is worth examining in some detail.

Government moves against Coca-Cola were orchestrated by Dr. Harvey Wiley, a zealous bureaucrat.  Wiley was the first head of the Bureau of Chemistry within the Department of Agriculture, the agency responsible for enforcing the Pure Food and Drug Act of 1906.  Wiley was one in a series of government officials, such as Hamilton Wright and Harry Anslinger, who made their living by campaigning against the evils of drug abuse.  These anti drug crusaders had more in common than just the desire to rid society of its drug problem; all were willing to use very bad, sometimes fraudulent science to advance their arguments.  The duel problem of "drug careerism", and the tendency to use political considerations as a means of determining scientific truth, have not gone away.  However, the issues were more clearly framed at the turn of the century.

During the early 1900s, the patent medicine [sic- a 'patent medicine' would be something that is patentable, aka a synthetic creation today known as a 'pharmaceutical', what is referred to here are actually 'proprietary medicines' generally blended compounds of naturally existing substances] market was crowded and fiercely competitive [ahh!!- generally meaning less expensive].  No central registry for these products ever existed, but informed estimates suggest that, at one time, more than 25,000 different patent medications were for sale in the United States.  As is true today, the success or failure of a new product was determined by the amount of money producers could spend on advertising.  Millions upon millions were spent promoting these products, and since the market was completely unregulated, even the most outrageous claims were permitted.  Revenues from patent [sic] drugmakers turned publishers into lobbyists for the drugmakers. Drug producers offered long term advertising contracts, but the contracts all contained automatic cancellation clauses, if by some accident, laws were passes prohibiting sales of heir product.  The publishers, of course, made every effort to see that that did not occur.

While some of the claims for Angelo Mariani's wine may have been overblown, there never was any doubt that the product contained wine and coca.  Using only coca leaf meant that there was a limit on how much cocaine Mariani could get into the wine.  By the mid 1890s, however, there was a glut of cocaine on the market, and patent [sic] drugmakers were able to dump large amounts of cocaine into their products [sic- I've seen no indication of this with the beverages, rather the problem were types of preparations meant for more direct use, such as intranasal or by injection], making them very popular, but addictive [sic- a better term would be 'toxic-maniac] and dangerous.

The medical literature of the late 1800s contains dozens of reports describing severe, occasionally lethal, reactions to cocaine anesthesia.  But as far as anyone knows, no one ever became ill, let alone addicted, to Vin Mariani, or any other coca-based wine.  Vin Mariani contained only a very small amount of cocaine, probably less than 6 mg per ounce, not enough to cause toxicity.  When combined with alcohol, however, a 6 to 8 ounce serving would have been more than enough to create feelings of well being.  The real secret behind Vin Mariani's success was not even known to Mariani, and was only discovered more than a century later.

In the late 1980s, the number of cocaine-related deaths in Miami, Florida began to explode.  lee Hearn, a toxicologist with the Miami Dade County Medical Examiner office, and Deborah Mash, a neurochemist at the University of Miami, first noted that when the deceased had been drinking alcohol and using cocaine at the same time, a new molecule, somewhat like cocaine, could be detected in their urine.  These observations were confirmed by Peter Jatlow at Yale, and another group of scientists in Barcelona.  It is now clear that cocaethylene has most of the same stimulant properties as cocaine, but that it lasts much longer.  Even though the cocaine content of Mariani's wine was relatively low, mixing the cocaine with alcohol resulted in a much higher effective dose!

Coca-Cola contained even less cocaine than Vin Mariani.  According to a formulation held by the great-grandson of Frank Robinson, one of Coca-Cola's founders, 10 pounds of coca leaf were used to make 36 gallons of syrup.  Coca leaf from South America contains very little cocaine, probably less than 0.5%, and not all of that can be extracted.  Thus Coca-Cola, as originally produced, would have contained about 100 mg of cocaine per gallon (10lb=22.5 kg, 55 x 22.5 kg = 112 mg) or 1.5 mg per ounce, only one-fourth the amount of cocaine found in Vin Mariani.  Such minute amounts of cocaine would certainly not have been enough to produce a detectable physiological response, and it is absurd to suggest that Coca-Cola ever had addictive properties, or that its cocaine content was responsible for its success.  Coca-Cola was successful for the very same reason that Vin Mariani was successful: it was brilliantly promoted.  Coca-Cola's managers were better salesmen than Mariani's, and Coca-Cola prospered, while Mariani gradually lost market share.  Coca-Cola continued to grow and prosper long after the cocaine had been dropped from the original formula.  Vin Mariani was not so well promoted, and after World War I, it simply faded from existence.